Zavicef (2 gm) | ঔষধের দাম ও নির্দেশিকা

ব্যবহার

This combination IV Infusion is indicated in- Complicated Intra-abdominal Infections (cIAI) Complicated Urinary Tract Infections (cUTI), including Pyelonephritis Hospital-acquired Bacterial Pneumonia and Ventilator-associated Bacterial Pneumonia (HABP/VABP)

ফার্মাকোলজি

Ceftazidime inhibits bacterial peptidoglycan cell wall synthesis following binding to penicillin binding proteins (PBPs), which leads to bacterial cell lysis and death. Avibactam is a non β-lactam, β-lactamase inhibitor that acts by forming a covalent adduct with the enzyme that is stable to hydrolysis. It inhibits both Ambler class A and class C β-lactamases and some class D enzymes, including extended-spectrum β-lactamases (ESBLs), KPC and OXA-48 carbapenemases, and AmpC enzymes. Avibactam does not inhibit class B enzymes (metallo-β-lactamases) and is not able to inhibit many class D enzymes.

সেবনবিধি

Dosage in Adult Patients with Creatinine Clearance (CrCl) greater than 50 mL/min- Infection Dose Frequency Infusion Time Duration of Treatment Complicated Intra-abdominalnInfections[used in combination with metronidazole] (cIAI) 2.5 grams Every 8 hours 2 hours cIAI: 5 to 14 dayscUTI: 7 to 14 daysHABP/VABP: 7 to 14 days Complicated Urinary Tract Infectionsincluding Pyelonephritis (cUTI) Hospital-acquired Bacterial Pneumonia and Ventilator-associated Bacterial Pneumonia (HABP/VABP) Dosage in Adult Patients with Creatinine Clearance (CrCl) less than 50 mL/min- Estimated CrCl (mL/minute) Dose Frequency 31 to 50 1.25 grams (ceftazidime 1 gram and avibactam 0.25 grams) intravenously Every 8 hours 16 to 30 0.94 grams (ceftazidime 0.75 grams and avibactam 0.19 grams) intravenously Every 12 hours 6 to 15 0.94 grams (ceftazidime 0.75 grams and avibactam 0.19 grams) intravenously Every 24 hours Less than or equal to 5 0.94 grams (ceftazidime 0.75 grams and avibactam 0.19 grams) intravenously Every 48 hours Dosage in Patients 3 months to < 18 years Infection Age Range Dose Frequency Infusion Time Duration ofTreatment cIAI and cUTIincluding Pyelonephritis 2 years to lessthan18 years 62.5 mg/kg to a maximum of 2.5 grams (Ceftazidime 50 mg/kg and avibactam 12.5 mg/kg to a maximum dose of ceftazidime 2 grams and avibactam 0.5 grams) Every 8 hours 2 Hours cIAI: 5 to 14 dayscUTI: 7 to14 days 6 months to lessthan 2 years 62.5 mg/kg (Ceftazidime 50 mg/kg and avibactam 12.5 mg/kg) 3 months to lessthan 6 months 50 mg/kg (Ceftazidime 40 mg/kg and avibactam 10 mg/kg) In Pediatric Patients 2 to < 18 years with Renal Impairment- Estimated eGFR(mL/min/1.73m2) Dose Frequency 31 to 50 31.25 mg/kg to a maximum of 1.25 grams (Ceftazidime 25 mg/kg and avibactam 6.25 mg/kg to a maximum dose of ceftazidime 1 gram and avibactam 0.25 grams Every 8 hours 16 to 30 23.75 mg/kg to a maximum of 0.94 grams (Ceftazidime 19 mg/kg and avibactam4.75 mg/kg to a maximum dose of ceftazidime 0.75 grams and avibactam 0.19 grams Every 12 hours 6 to 15 23.75 mg/kg to a maximum of 0.94 grams (Ceftazidime 19 mg/kg and avibactam4.75 mg/kg to a maximum dose of ceftazidime 0.75 grams and avibactam 0.19 grams) Every 24 hours Less than or equal to 5 23.75 mg/kg to a maximum of 0.94 grams (Ceftazidime 19 mg/kg and avibactam4.75 mg/kg to a maximum dose of ceftazidime 0.75 grams and avibactam 0.19 grams) Every 48 hours

পার্শ্বপ্রতিক্রিয়া

Adult cIAI, cUTI and HABP/VABP Patients: The most common adverse reactions in cIAI (≥ 5%, when used with metronidazole) patients are diarrhea, nausea and vomiting. The most common adverse reactions (3%) in cUTI patients are diarrhea and nausea. The most common adverse reactions (≥5%) in HABP/VABP patients were diarrhea and vomiting. Pediatric cIAI and cUTI Patients: The most common adverse reactions (>3%) in pediatric patients were vomiting, diarrhea, rash, and infusion site phlebitis

সতর্কতা

Decreased efficacy in adult cIAI patients with baseline CrCl of 30 to less than or equal to 50 mL/ min: Monitor CrCl at least daily in adult and pediatric patients with changing renal function and adjust the dose of this IV infusion accordingly.Hypersensitivity reactions: Includes anaphylaxis and serious skin reactions. Cross-hypersensitivity may occur in patients with a history of penicillin allergy. If an allergic reaction occurs, discontinue this IV infusion.Clostridium difficile-associated diarrhea (CDAD): CDAD has been reported with nearly all systemic antibacterial agents, including this IV infusion. Evaluate if diarrhea occurs.Central Nervous System Reactions: Seizures and other neurologic events may occur, especially in patients with renal impairment. Adjust dose in patients with renal impairment.

গর্ভাবস্থায় ও স্তন্যদানকালে ব্যবহার

There are no adequate and well-controlled studies of this IV infusion, ceftazidime, or avibactam in pregnant women. No information is available on the effects of ceftazidime and avibactam on the breast-fed child or on milk production.

সংরক্ষণ

Store at temperature not exceeding 25°C in a dry place. Protect from light & moisture.

বিকল্প ওষুধ

Zavicef 2 gm IV Infusion

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