Vogli (03 mg) | ঔষধের দাম ও নির্দেশিকা

ব্যবহার

Voglibose is an alpha-glucosidase inhibitor & indicated- in non-insulin-dependent diabetes mellitus (NIDDM) patients as immunotherapy in combination with other oral hypoglycaemic agents in addition to insulin in diabetes mellitus patients in prevention of onset of type 2 diabetes mellitus in impaired glucose tolerance ... Read moreVoglibose is an alpha-glucosidase inhibitor & indicated- in non-insulin-dependent diabetes mellitus (NIDDM) patients as immunotherapy in combination with other oral hypoglycaemic agents in addition to insulin in diabetes mellitus patients in prevention of onset of type 2 diabetes mellitus in impaired glucose tolerance in elderly patients and in those with hepatic dysfunction or mild to moderate renal impairments in whom other oral hypoglycaemic agents are contraindicated or they need to be used with caution, it will be helpful. in glycogen storage disease: It is helpful in prevention of hypoglycaemia in patients with type lb glycogen storage disease. in non-diabetic hyperinsulinemia, it is helpful in preventing hypoglycaemic attacks.

ফার্মাকোলজি

Alpha-glucosidase inhibitors are saccharides that act as competitive inhibitors of enzymes needed to digest carbohydrates: specifically alpha-glucosidase enzymes in the brush border of the small intestines. The membrane-bound intestinal alpha-glucosidases hydrolyze oligosaccharides, trisaccharides, and disaccharides to glucose and other monosaccharides in the small intestine. Acarbose also blocks pancreatic alpha-amylase in addition to inhibiting membrane-bound alpha-glucosidases. Pancreatic alpha-amylase hydrolyzes complex starches to oligosaccharides in the lumen of the small intestine. Inhibition of these enzyme systems reduces the rate of digestion of complex carbohydrates. Less glucose is absorbed because the carbohydrates are not broken down into glucose molecules. In diabetic patients, the short-term effect of these drugs therapies is to decrease current blood glucose levels: the long term effect is a small reduction in hemoglobin-A1c level.

সেবনবিধি

Adult Dose: Usually, Voglibose tablets are orally administered in a single dose of 0.2 mg, 3 times a day, before each meal. If the effect is not sufficient, the quantity of a single dose may be increased up to 0.3 mg.Paediatrics: The safety and effectiveness of Voglibose in children has not been established.Geriatrics: Since elderly patients generally have a physiological hypofunction, it is desirable that such caution should be taken as starting the administration at a lower dose (e.g. 0.1 mg at a time). Furthermore, this drug should be carefully administered under close observation, through the course of the disease condition, with careful attention to the blood sugar level and the onset of gastrointestinal symptoms.Dosage in Renal Failure: Voglibose is poorly absorbed after oral doses and renal excretion is negligible, suggesting that no dose adjustment is required. However, pharmacokinetic studies in patients with renal insufficiency are not available.

পার্শ্বপ্রতিক্রিয়া

Voglibose unlikely to produce hypoglycaemia in overdose, but abdominal discomfort and diarrhea may occur. Moreover loose stools, abdominal pain, constipation, loss of appetite, urge to vomit (nausea), vomiting, heartburn, increased gas, and intestinal obstruction like symptoms due to increased intestinal gas may cause. Oral hypoglycaemic agents plus Voglibose may cause hypoglycaemia (0.1% to <5%), delay in digestion and absorption of disaccharides, fulminant hepatitis, serious liver dysfunction with increased liver enzymes, jaundice, anemia, numbness, edema, blurred vision, hot flushes, malaise, weakness, hyperkalemia, increased pancreatic enzyme (serum amylase).

সতর্কতা

The administration of Voglibose tablets should be limited to patients who have established diabetes as there are certain other disease conditions such as abnormal glucose tolerance and positive urinary sugar that represent diabetes-like symptoms (renal glycosuria, senile abnormal glucose tolerance, abnormal thyroid function, etc.) In patients who are being managed with lifestyle modifications (diet and/or exercise), this drug must be given only when the 2-hour postprandial blood glucose levels are ≥200 mg/dL. During administration of this drug, disease progression should be closely observed with monitoring of blood glucose levels at regular intervals. If the effect on postprandial glucose levels is not satisfactory even after the administration of this drug for 2 to 3 months (postprandial glucose ≥200mg/dL), consider a change to more appropriate treatment. After administration of this drug, if sufficient control of blood glucose is achieved (postprandial glucose ≤160 mg/dL) and can satisfactorily be maintained with lifestyle therapy or with additional use of oral hypoglycaemic drugs or insulin preparations, the administration of Voglibose tablet should be discontinued, and subsequent progresses of disease should be monitored.

গর্ভাবস্থায় ও স্তন্যদানকালে ব্যবহার

The safety of Voglibose in pregnancy has not been established. However, no adequate and well controlled studies have been found on pregnant women. Although the levels of Voglibose reached in human milk are exceedingly low, it is recommended that Voglibose may not be administered to such women.

মাত্রাতিরিক্ত ব্যবহার

Unlike sulfonylureas or insulin, an overdose of Voglibose tablets will not result in hypoglycaemia. An overdose may result is transient increase in flatulence, diarrhoea and abdominal discomfort. Because of lack of extra-intestinal effects soon with Voglibose, no serious systemic reactions are expected in the event of an overdose.

সংরক্ষণ

Store in a cool (below 30°C) and dry place, away from light. Keep out of the reach of children.

বিকল্প ওষুধ

Vogli 03 mg Tablet

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