Napxon-P (250 mg) | ঔষধের দাম ও নির্দেশিকা

ব্যবহার

ন্যাপ্রোক্সেন নিম্নোক্ত উপসর্গে নির্দেশিত- রিউমাটয়েড আর্থ্রাইটিস অস্টিওআর্থ্রাইটিস অ্যানকাইলোজিং স্পন্ডিলাইটিস জুভেনাইল আর্থ্রাইটিস টেন্ডোনাইটিস বার্সাইটিস গেটে বাতের লক্ষণসমূহ নিরাময়ে এছাড়াও প্রাইমারি ডিসমেনোরিয়া এবং ব্যথার চিকিৎসায় এটি ব্যবহৃত হয়।

ফার্মাকোলজি

ন্যাপ্রোক্সেন একটি নন-স্টেরয়ডাল এন্টি-ইনফ্লামেটরী ড্রাগ (NSAID) যার প্রদাহবিরোধী, ব্যথানাশক ও জ্বর উপশমকারী গুনাবলী আছে। এটি গ্যাষ্ট্রোইন্টেষ্টাইনাল ট্র্যাক্ট থেকে দ্রূত পরিশোষিত হয় এবং ৯৫% বায়োএ্যাভেইলএবিলিটি অর্জন করে।

সেবনবিধি

Naproxen oral preparations should be taken with water preferably after meals.Naproxen Enteric Coated Tablet: Adult: For rheumatoid arthritis/ osteoarthritis/ ankylosing spondylitis: For adults 500-1000 mg per day taken in two devided doses at 12- hour intervals. The maintenance dose is usually 500 mg per day taken in two devided doses at 12 - hour intervals. The total daily dose of Naproxen should not exceed 1000 mg maintaining 12-hour intervals. For acute gout: 750 mg should be given initially, then 250 mg every 8 hours until the attack has passed. Children under 16 years are not recommended. For dysmenorrhoea: For adults 500 mg should be given initially, followed by 250 mg at 6-8 hour intervals for upto 5 days, if necessary. For other indications like analgesia and acute musculoskeletal disorders: 500 mg should be given initially, followed by 250 mg at 6-8 hour intervals, if necessary. Naproxen Enteric Coated Tablet: Children: Children under 16 years are not recommended.Naproxen Suspension: Children:For juvenile rheumatoid arthritis: The usual dose for children over 2 years is 10 mg/kg/day given as two divided doses at 12-hour intervals. Therapy in children under 2 years of age is not recommended. The following may be used as a guide for dosage of suspension: 13 kg (29 lb) 2.5 mL b.i.d. 25 kg (55 lb) 5 mL b.i.d. 38 kg (84 lb) 7.5 mL b.i.d. Naproxen Gel: Is to be applied 2-6 times a day as required and is not recommended for use in children.

পার্শ্বপ্রতিক্রিয়া

Most frequently reported side effects include following: Gastrointestinal: Heartburn, abdominal pain, nausea, diarrhea, dyspepsia. Central Nervous System: Headache, vertigo, drowsiness. Dermatological: Pruritus (itching), purpura. Cardiovascular: Edema, palpitation. Others: Visual disturbances, hearing disturbances.

সতর্কতা

Renal effects: As with other non-steroidal anti- inflammatory drugs, long-term administration of naproxen to animal has resulted in renal papillary necrosis and other abnormal renal pathology. In humans, there have been reports of acute interstitial nephritis, hematuria, proteinuria and occasionally nephrotic syndrome associated with Naproxen-containing products and others NSAIDs since they have been marketed. Naproxen and its metabolites are eliminated primarily by the kidneys; therefore, the drug should be used with caution in patients with significantly impaired renal function, and the monitoring of serum creatinine and/or creatinine clearance is advised in these patients. Caution should be used if the drug is given to the patients with creatinine clearance of less than 20ml/min because accumulation of naproxen metabolites has been seen in such patients.Hepatic effects: There have been a few reports of moderate to severe jaundice attributed to Naproxen.

গর্ভাবস্থায় ও স্তন্যদানকালে ব্যবহার

Most non-steroidal anti-inflammatory drugs may have an adverse effect on the fetus through their pharmacological properties. Naproxen causes a delay in parturition in animals and has been associated with premature closure of the ductus arteriosus and severe pulmonary hypertension in infants born to mothers taking Naproxen. The use of Naproxen in the first and third trimesters requires careful balancing of the benefits to the mother against the possible risks to the fetus. Naproxen is excreted in small amounts in the breast milk for nursing mothers. The amount of Naproxen distributed into breast milk is considered by some authorities to be too small to be harmful to a breast-fed infant although some manufacturers recommend that breast feeding should be avoided during Naproxen therapy.

সংরক্ষণ

আলো ও আর্দ্রতা থেকে দূরে, ৩০°সেঃ তাপমাত্রার নীচে রাখুন। শিশুদের নাগালের বাইরে রাখুন।

বিকল্প ওষুধ

Napxon-P 250 mg Tablet

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