Insul (null) | ঔষধের দাম ও নির্দেশিকা

ব্যবহার

This combination injection is indicated for- Treatment of all patients with type 1 diabetes Treatment of patients with type 2 diabetes who are not adequately controlled by diet and/ or oral hypoglycemic agents For the initial stabilization of diabetes in patients with diabetic ketoacidosis, hyperosmolar non-ketotic syndrome and during periods of stress such as severe infections and major surgery in diabetic patients Treatment of gestational diabetes

ফার্মাকোলজি

The blood glucose lowering effect of insulin is due to the facilitated uptake of glucose following binding of insulin to receptors on muscle and fat cells and to the simultaneous inhibition of glucose output from the liver. Insulin has a half-life of a few minutes in the blood stream. No profound binding to plasma proteins. An average action profile after subcutaneous injection indicates: Onset of action- within 30 minutes Peak plasma levels attained between 1-3 hours Duration of action- approximately 18-24 hours

সেবনবিধি

Dosage is individual and determined by the physician in accordance with the needs of the patient.The average range of total daily insulin requirement for maintenance therapy in type 1 diabetic patients lies between 0.5 and 1.0 IU/Kg. In pre-pubertal children it usually varies from 0.7 to 1.0 IU/ Kg.The daily insulin requirement may be higher in patients with insulin resistance (e.g. during puberty in the young or due to obesity) and lower in patients with endogenous insulin production or during the period of partial remission.Initial dosage for type 2 diabetic patients are often lower, e.g. 0.3 to 0.6 IU/ Kg/ Day. An injection should be followed within 30 minutes by a meal or snack containing carbohydrates.

পার্শ্বপ্রতিক্রিয়া

Adverse drug reactions observed in patients using human insulin are mainly dose-dependent and due to the pharmacologic effect of insulin. As for other insulin products, hypoglycemia, in general is the most frequently undesirable effect. It may occur if the insulin dose is too high in relation to the insulin requirement. Lipodystrophy may occur at the injection site as a consequence of failure to rotate injection sites within an area. Symptoms of generalized hypersensitivity may include generalized skin rash, itching, sweating, gastrointestinal upset and angioneurotic oedema, difficulties in breathing, palpitation and reduction in blood pressure. Generalised hypersensitivity reactions are potentially life threatening. Edema may occur upon initiation of insulin therapy. These symptoms are usually of transitory nature.

সতর্কতা

Inadequate dosing or discontinuation of treatment, especially in type 1 diabetes, may lead to hyperglycemia. In type 1 diabetes, untreated hyperglycemic events eventually leads to diabetic ketoacidosis which is potentially lethal.Hypoglycemia may occur if the insulin dose is too high in relation to the insulin requirement.Transferring a patient to another type or brand of insulin should be done under strict medical supervision.Changes in strength, brand (manufacturer), type (rapid acting insulin, dual acting insulin, intermediate and long acting insulin etc.), species (animal, human insulin analogue) and/or method of manufacture (recombinant DNA versus animal source insulin) may result in the need for a change in dosage.Before traveling between different time zones, the patients should be advised to consult the doctor, since this may mean that the patients has to take insulin and meals at different time.It should not be used if there are clumps in the insulin after mixing and should not be used if solid white particles stick to the bottom or wall of the bottle, giving it a frosted appearance.

গর্ভাবস্থায় ও স্তন্যদানকালে ব্যবহার

There are no restrictions on the treatment of diabetes with insulin during pregnancy as insulin does not pass the placental barrier. Both hypoglycemia and hyperglycemia, which can occur in inadequately controlled diabetes therapy, increase the risk of malformations and death in utero. Insulin requirements usually fall in the first trimester and increase subsequently during the second and third trimesters. After delivery, insulin requirements return rapidly to pre-pregnancy values. Insulin treatment of the nursing mother involves no risk to the baby. However, the insulin dosage, diet or both may need to be adjusted.

মাত্রাতিরিক্ত ব্যবহার

Insulins have no specific overdose definitions. However, hypoglycemia may develop over sequential stages: Mild hypoglycemic episodes can be treated by oral administration of glucose or sugery products. Severe hypoglycemic episodes, where the patient has become unconscious, can be treated by Glucagon (0.5 to 1 mg) given intramuscularly or subcutaneously by a trained person or glucose given intravenously by a medical professional. Glucose must also be given intravenously, if the patient does not respond to Glucagon within 10 to 15 minutes. Upon regaining consciousness administration of oral carbohydrate is recommended for the patient in order to prevent relapse.

সংরক্ষণ

Insulin preparations should be stored between 2°C and 8°C (in a refrigerator). Insulin preparations which have been frozen must not be used. Insulin preparation should be kept in the outer carton in order to protect from light. Insulin preparations should be protected from excessive heat or sunlight. When in use the cartridge should not be refrigerated. Once in use the cartridge may be used for up to 6 weeks when stored below 25 o C or 4 weeks when stored below 30°C. Preparation should be mixed thoroughly before use, preferably by rolling the cartridges slowly between the hands.

বিকল্প ওষুধ

Insul SC Injection

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